However, evaluation of ILD patients classified per radiological pattern (from UIP to alternative diagnosis) showed that the association of anti-Mi-2β with histological UIP persisted within each radiological group (OR range 4.3–10, all p<0.05), indicating that the association of serum Mi-2β antibodies with histological UIP was independent of the patients’ corresponding radiological pattern. This evidence concerns the gene CHD4 and interstitial lung disease.