Prevalence of antibodies Mi-2β, SRP and Ku was significantly higher in non-CTD-ILD compared to CTD-ILD (all p<0.05, see Table 2), in particular in IPF (respectively 26.5%, 11.8% and 8.8%) and unclassifiable IIP (respectively 17.9%, 14.2% and 7.5%; S4 Table in S1 File). This evidence concerns the gene CHD4 and interstitial lung disease.