The pre-synaptic proteins vGLUT1 and Synapsin 1 were decreased by 70% in MAP2+ cells (60% in overall cells) and by 60%, respectively, upon infection with SARS-CoV-2 compared to mock conditions, which were rescued upon treatment with SOF post-infection (Figs 3A–3F, S5A, S5B, S6B, and S6C). Here, SYN1 is linked to infection.