These proteins were MSR1, IL-18R1, IL6, EDA2R, HGF, SCARF2, CTSC, SCARA5, SIGLEC1, NRP2, EFNA4, SCARB2, EZR, LAYN, CLM-1 and CTSS, which are represented in several different disease areas including pulmonary, cardiovascular, neurological, skeletal, hemic, lymphatic, metabolic, and inflammatory diseases such as rheumatic disease, systemic sclerosis, and Sjögren’s syndrome, but also demyelination, neuropathies, and prostate cancer (S2 and S3 Tables). The gene discussed is CTSS; the disease is rheumatic disorder.