MSA+ count from the lesional AD skin was significantly higher than the MSA+ count from skin without lesion (adjusted P value = 0.035), the MSA- count from the skin without lesion (adjusted P value = 0.0006) and both MSA+ and MSA- from the skin of non-AD children (adjusted P values = 0.0001 and 0.023, respectively) (Fig 1). The gene discussed is TPO; the disease is Alzheimer disease.