Results from the severe COVID-19 outcome analyses of TLR7 with other masks also nearly reach our statistical significance threshold, with larger effects found in the M1 mask (OR: 13.6, 95% CI: 4.41–44.3, p = 1.64x10-5) and smaller effect in the M4 mask (OR: 3.12, 95% CI: 1.91–5.10, p = 5.30x10-6), though the latter was balanced by smaller standard errors due to the larger number of cases (3275 cases in M4 vs 1577 in M1), as expected. Here, TLR7 is linked to COVID-19.