In the meta-analyses, we also found that pLoFs (M1) in MARK1 were associated with a 23.9-fold increase in the odds of severe COVID-19 (95% CI: 6.5–88.2, p = 1.89x10-6), and a 12.3-fold increase in the odds of hospitalisation due to COVID-19 (95% CI: 4.8–31.2, p = 1.43x10-7). The gene discussed is MARK1; the disease is COVID-19.