TLR7 and COVID-19: Of specific interest, we observed that carrying a predicted loss of function or in-silico highly deleterious missense variant (i.e., mask M3) in the toll-like receptor 7 (TLR7) gene was associated with a 5.3-fold increase (95% CI: 2.7–10.1, p = 5.41x10-7) in odds of severe COVID-19.