MAPT and Alzheimer disease: For instances, in AD is described an accumulation of amyloid‐β (Aβ) in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, leading to neurodegeneration (Ising & Heneka, 2018), the NLRP3 inflammasome has been related to the advance of Aβ pathology in AD models in mice.