In the ‘Primary Immunodeficiency signaling’ pathway not only RAG1, RAG2 and IL7R were downregulated but also AICDA (Activation Induced Cytidine Deaminase) and IGLL1 for which there is strong evidence that their expression is regulated by FOXO1 (for reviews, see Szydłowski et al. 2014; Cabrera-Ortega et al. 2017). The gene discussed is RAG2; the disease is inborn error of immunity.