RAG1 and inborn error of immunity: The genes in this data set associated with B Cell Development are CD79B, HLA-DQA2, IL7R, RAG1 and RAG2. Primary immunodeficiency signaling was represented by downregulation of AICDA, IGLL1/IGLL5, IL7R, RAG1 and RAG2. As mentioned above, RAG1 and RAG2 are the most highly downregulated genes by PFOA in Namalwa cells showing a p value of 2.44 × 10–15 and 5.53 × 10–13, respectively (Table 2).