As proof of principle for the assertion that PFKFB3-driven glycolysis in alveolar epithelia plays a functional role in alveolar inflammation during ARDS, we first pursued studies to reconstitute the phenotype we had observed in Pfkfb3loxP/loxP SPC-Cre-ER+ mice. The gene discussed is PFKFB3; the disease is acute respiratory distress syndrome.