CXCL1 and acute respiratory distress syndrome: We found that mice treated with 3PO experienced exacerbation of lung injury, including increased protein levels in the bronchoalveolar lavage fluid (BALF) and elevated mRNA expression of proinflammatory cytokines IL-6 and CXCL1 in their lungs (Figure 2, B–D), leading to exacerbated histologic lung injury and histologic ALI scores (Figure 2, E and F).