Multiple patients with autosomal recessive (AR) complete TYK2 and IL-12Rβ1 deficiencies have been diagnosed with TB (Altare et al., 2001; Kreins et al., 2015; Boisson-Dupuis and Bustamante, 2021; Ogishi et al., 2022). The gene discussed is IL12RB1; the disease is tuberculosis.