IFNG and Mendelian susceptibility to mycobacterial diseases: ITK deficiency does not impair the development of IFN-γ–producing lymphocyte subsets, including TH1, TH1*, Vδ2+ γδ T, MAIT, iNKT, and NK lymphocytes, unlike genetic etiologies of MSMD, such as T-bet and RORγ deficiencies (Okada et al., 2015; Yang et al., 2020).