Although there were substantially more enriched TFs in the AD‐metabolic proteome (Table S5), lipid‐associated TFs such as estrogen‐related receptor alpha (ESRRα) and sterol regulatory element‐binding transcription factor 1 (SREBF1) were over‐represented in the AD‐metabolic transcriptome and proteome (FDR p < 0.050, Figure 3b). Here, SREBF1 is linked to Alzheimer disease.