We found consistent perturbations of lipid and energy metabolism across three AD multi‐omics data sets compiled from previous studies, from which we extracted 133 lipid species predicted to be dysregulated in AD which we then validated in an ABCA7 knockout (KO) mouse data set acquired with ultraperformance liquid chromatography‐mass spectrometry (UPLC‐MS). Here, ABCA7 is linked to Alzheimer disease.