Kondo [19] reported that alkaline phosphatase level (> 125 U/L), alpha-fetoprotein level (within 20–400 or >400 ng/mL), protein induced by vitamin K absence-II (within 40–400 or > 400 mAU/mL), tumor number, diameter, pseudocapsule, tumor growth pattern, and intratumor hemorrhage were independent prognostic factors for HCC. This evidence concerns the gene AFP and hepatocellular carcinoma.