Previous plasma metabolic profiling by nuclear magnetic resonance spectroscopy and PCA graph analysis for 108 individuals with demyelinating disorders (34 with relapsing-remitting MS, 54 with AQP4-Ab NMOSD, and 20 with MOG-Ab disease) suggested that relapsing-remitting MS could be differentiated from aquaporin-4 IgG-positive NMOSD through various combinations of scyllo-inositol, myo-inositol, lipoprotein particles, histidine, glucose, lactate, alanine, formate, and leucine that differed between the groups [10]. This evidence concerns the gene AQP4 and demyelinating disease.