The median value of percentage of CD8+ Tregs (CD3+CD8+CD25+Foxp3+) among all patients with COVID-19 were higher than controls (0.4 [range, 0–4.2] vs. 0.3 [range, 0–1.5], Mann–Whitney U p = 0.001) (Figure 3B). This evidence concerns the gene CD8A and COVID-19.