TNF and juvenile idiopathic arthritis: Several biologic agents are used in drug-resistant JIA, including etanercept (TNF-soluble receptor), Adalimumab (humanised anti-TNF antibody), Abatacept (T-cell co-stimulation inhibitor), Anakinra (IL-1 receptor antagonist), Canakinumab (Humanised anti-IL-1 antibody) [25].