Blood samples from depression patients had increased expression levels of B cells naive, B cells memory, T cells CD8, and Mast cells resting The correlation of S100A12, TIGIT, SERPINB2, GRB10, and LHFPL2 with immune cells indicated that these genes were associated with the expression levels of macrophages MO, mast cells resting, macrophages M2, neutrophils, monocytes, B cells naive, T cells CD4 memory resting, and T cells CD8. This evidence concerns the gene LHFPL2 and major depressive disorder.