On the other hand, other brain regions containing TH+ neurons, in particular the SNpc and locus coeruleus (LC), are intact in Tg2576 mice at least until 6 months of age, suggesting that the early degeneration is selective for mesocorticolimbic neurons in the VTA and can account for the AD-like memory symptoms in these mice (114). The gene discussed is TH; the disease is Alzheimer disease.