CD4 and infection: Later during infection, type I IFN activities influence T cells with the induction of cytokine secreting CD4+ T cells and the stimulation of Granzyme B (GzmB) and IFNγ expression by cytotoxic CD8+ T cells (Daheshia et al., 1999; Liu et al., 2000; Carr and Noisakran, 2002; Knickelbein et al., 2008; Vahed et al., 2019).