Univariate logistic regression analysis of risk factors for ICU admission in patients with severe leptospirosis revealed that dyspnea, altered consciousness, neutrophil count, lactate dehydrogenase, blood urea nitrogen, creatine kinase isoenzyme, activated partial thrombin time, d-dimer, c-reactive protein were significantly associated with ICU admission (Table 4). The gene discussed is CRP; the disease is leptospirosis.