MEN1-related angiofibromas differ from those seen in TSC, in which the lesions are larger, more numerous, and earlier in onset; in TSC, the angiofibromas are also predominantly in a malar distribution and do not appear on the upper lip and its vermilion border as can be seen in MEN1 patients (13, 34). The gene discussed is MEN1; the disease is Angiofibromas.