In 32 patients, angiofibromas and/or collagenomas were highly prevalent (29/32; 91%), including one patient in whom the clinical diagnosis of MEN1 was made before the biochemical confirmation of primary hyperparathyroidism (PHPT); no patients in a control group were identified to have multiple angiofibromas or collagenomas. This evidence concerns the gene MEN1 and Angiofibroma.