In addition to occurring sporadically in the general population, lipomas can arise in various genetic disorders, including MEN1, encephalocraniocutaneous lipomatosis, KCNK9 Imprinting Syndrome, PTEN Hamartoma Tumor Syndrome, PIK3CA-Related Overgrowth Spectrum, Birt-Hogg-Dubé Syndrome, and Myoclonic Epilepsy Associated with Ragged Red Fibers [See GeneReviews® (33)]. This evidence concerns the gene MEN1 and Birt-Hogg-Dubé syndrome.