Similar to the defining MEN1 “3Ps”, these dermatologic neoplasms have also been shown to have LOH with allelic deletion of the MEN1 gene (27, 28), a finding not seen in a melanocytic nevus or acrochordon from MEN1 patients (27), in an angiofibroma from a patient with tuberous sclerosis (27), or in 19 sporadic angiofibromas (29), although two of the sporadic tumors were identified to have somatic missense MEN1 mutations. The gene discussed is MEN1; the disease is tuberous sclerosis.