Most recently, in a large study sequencing 34 putative germline susceptibility genes in 60,466 women with breast cancer and 53,461 controls, protein-truncating (odds ratio 0.37 [95% CI 0.07–1.97; p=0.24]) and rare missense MEN1 variants (odds ratio 0.86 [95% CI 0.66–1.12; p=0.25]) were not associated with an increased breast cancer risk (167). The gene discussed is MEN1; the disease is breast carcinoma.