Therefore, in our study, the initial FSH dose was negatively correlated with the number of cleavage-stage embryos available after the initial dose exceeded 200 IU per day even after adjusting for female age, BMI, weight, infertility factors, duration of infertility, AMH, bFSH level, AFC, and the proportions of patients with POR and PCOS. This evidence concerns the gene FSHB and polycystic ovary syndrome.