First, having a clinical history of depression among the PD patients was related to a DMR in chromosome 1, in a genetic region near PM20D1, SLC41A1, RAB29, and NUCKS1. The most significant individual CpG related to depression in the region we identified was cg15199181 (FDR = 0.02). The gene discussed is PM20D1; the disease is major depressive disorder.