First, having a clinical history of depression among the PD patients was related to a DMR in chromosome 1, in a genetic region near PM20D1, SLC41A1, RAB29, and NUCKS1. The most significant individual CpG related to depression in the region we identified was cg15199181 (FDR = 0.02). Here, SLC41A1 is linked to depressive symptom measurement.