PCNA and glioma: Our previous characterization of the SVZ-EGFRwt model shows that these cells express MES features.22,23 Interestingly, an in-silico analysis of two proliferation markers, PCNA and MKI67, was performed, and it was found that MES gliomas expressed the lowest levels of these genes (Supplementary Figure 7A), suggesting that tumors with this phenotype are less proliferative than the other 2 subtypes (classical (CL) and PN).