However, 6 years later, the success of apolipoprotein E (ApoE)-knockout pigs reproduced the human-like atherosclerotic lesions induced by a high-fat, high-cholesterol diet when the model had severe hypercholesterolemia (Fang et al., 2018), making a better representation of atherosclerosis in transgenic pig models. This evidence concerns the gene APOE and familial hypercholesterolemia.