One of the cases for the Yucatan transgenic pig is generating male and female LDLR+/-pigs with techniques of recombinant adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer in 2014, providing a better model of large animals in familial hypercholesterolemia and atherosclerosis (Wells and Prather, 2017). Here, LDLR is linked to familial hypercholesterolemia.