FSTL3 not only increase myocardial fibrosis (Panse et al., 2012), promote bone formation and strengthening (Bartholin et al., 2005), regulates the reproductive system, but also can enhance the migration and invasion abilities of a variety of malignant tumor cells by increasing glycolysis, decreasing PH in the tumor microenvironment and resulting in EMT of tumor cells, which is closely associated with the poor prognosis of patients (Razanajaona et al., 2007; Li et al., 2021a). This evidence concerns the gene FSTL3 and neoplasm.