KLF4 and head and neck cancer: Chen et al. found that Twist1 activates Kruppel-like factor 4 (KLF4) through Jagged1/Notch signaling, induces head and neck cancer cells (HNC) to exhibit stem-like properties, and causes endothelial differentiation (Chen et al., 2014), suggesting that KLF4 may act as a key mediator of ECs differentiation from pluripotent stem cells.