FSTL3 may be a potential binding partner of ADAM12. FSTL3 and ADAM12 perform similar functions to regulate tumor metastasis and immune infiltration in gastric cancer. In addition, FSTL3 overexpression promotes F-actin and BMP/SMAD signaling to activate EMT and M2 macrophage activation. This evidence concerns the gene ADAM12 and neoplasm.