Follistatin-like protein 3 (FSTL3) can play an active or inhibitory role in human physiology processes, non-tumor pathophysiologies and cancers by interacting with a disintegrin and metalloproteinase (ADAM) 12, TGF-β ligands and regulates the expression of zyxin, sirtuin-1 (SIRT1), and sclerostin (SOST) (Nam et al., 2015), proteins associated with cell survival, anti-aging, and bone formation and strengthening. Here, SIRT1 is linked to cancer.