FOLH1 and Familial prostate cancer: Although it is believed that it is only synthetized in brain, the prostate expresses the NAA synthetizing enzyme Glutamate carboxipeptidase II (NAAG peptidase) also named folate hydrolase (FolH1) and prostate specific membrane antigen (PSMA), which increases to the point of being considered one of the best tumor markers for prostate cancer (Kaewput and Vinjamuri, 2022; Schoder et al., 2022).