SHMT2 and leukemia: According to the subtype of leukemia, miR-193b can be inversely correlated with c-kit levels, linked to cell growth (51), contributing to the expression of Smoothened to activate the GLI/Hh signaling, promoting cell survival and proliferation (52), or targeted the MYB oncogene, MCL1, CCND1, 14-3-3, SHMT2, AKR1C2 (53, 54).