However, we speculate that, by repressing the expression of RPS3A and RPS7 ribosomal proteins, miR-125b and miR-15b might alleviate the breakdown of aberrant RNAs, altering the translatome of B-CLL cells in a wat that results in acquisition of a less aggressive resting phenotype. The gene discussed is RPS3A; the disease is B-cell chronic lymphocytic leukemia.