applied CUDC-907, a dual inhibitor of PI3K/Akt/mTOR pathway and histone deacetylases 2 (HDAC2) to human keloid fibroblasts (KFs), resulting in suppressed KF proliferation, migration, collagen production as well as reduced TGF-β1 in vitro (Figure 5C) (92). Here, HDAC2 is linked to keloid.