We hence first recruited a cohort of first-episode schizophrenia (FES) patients and healthy controls (HCs) to compare gene expressions in their peripheral blood cells, and we next examined Plxn/Sema expressions in mice undergoing chronic unpredictable stress (CUS) and further studied alterations of anxiety behaviors along with glial activation of mice after intra-amygdaloid functional blocking of Plxnb2 using a monoclonal antibody (mAb). Here, PLXNB2 is linked to schizophrenia.