IFITM3 and viral infectious disease: concluded that different inflammatory conditions, such as viral infection and aging, can induce the release of pro-inflammatory cytokines from astrocytes and microglia, which in turn elevate the expression of IFITM3 in neurons and astrocytes, and IFITM3 binds to active γ-secretase complexes, increasing Aβ production and increasing the risk of AD (66).