IFIT2 and viral infectious disease: The human IFIT gene family generally consists of four members: IFIT1, IFIT2 (ISG54, p54), IFIT3 (ISG60, p60), and IFIT5 (ISG58, p58), whereas the mouse IFIT gene family encodes for three relevant genes: IFIT1, IFIT2 and IFIT3 (ISG49, p49), which are induced during IFN signaling pathway, viral infection or other PAMP recognition and have critical roles in host antiviral defense (159, 160).