In patients with Rasmussen encephalitis (RE) caused by infection with HCMV viruses, IFITM3 was detected in the neurons of brain tissue, and there was colocalization of HCMV and IFITM3, suggesting that HCMV infection may induce IFITM3 expression in neurons and that IFITM3 can effectively inhibit HCMV infection and participate in the immune response to HCMV infection in RE brain tissue (64). This evidence concerns the gene IFITM3 and cytomegalovirus infection.