Among the 13 members of the TLR family including transmembrane TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10, and endosomal TLR3, TLR7, TLR8, TLR9, TLR11, TLR12, and TLR13, the most relevant TLRs related to macrophage polarization in cancer context are TLR2/TLR6 (114), TLR3 (114, 115), TLR4 (115, 116) and TLR7/8 (117). Here, TLR4 is linked to cancer.