Interestingly, it has been shown that the mechanism by which SARS-CoV-2 can inhibit MHC class I pathway is the suppression both at transcriptional and functional level of NLRC5 in the lung and airway epithelial cells during infection, consequently interfering with the CD8 T cell action and leading to higher risk of exacerbation of viral loads and prolonged infection (34). This evidence concerns the gene NLRC5 and infection.