HLA-C and infection: A role for reduced KIR/HLA-C combination as risk factor for severe or fatal SARS-CoV-2 evolution has been demonstrated (in a cohort of patients coming from the same geographic area of this study); so a reduction of HLA-C expression such that we have found may reduce the activity of NK cells (in particular the memory-like NK) against the virus and thereby contribute to impaired viral clearance at early stages of infection (53).