With the widespread use of anti-retroviral therapy (ART), the viral load (VL) of most human immunodeficiency virus (HIV)/Acquired Immure Deficiency Syndrome (AIDS) patients has been controlled, and peripheral blood CD4+ T-lymphocyte (CD4+ T cell) counts have returned to relatively normal levels, but approximately 15-30% of ART-treated people living with HIV (PLWH) still have low CD4+ T cell counts despite adequate control of viral replication (1, 2). The gene discussed is CD4; the disease is AIDS.