Although we have revealed and proved that GXNI can play an anti-acute myocardial ischemia-reperfusion injury via inhibiting the CXCR1-NF-κB-COX-2/ICAM-1/VCAM-1-mediated IL-8 signaling pathway, there are still some issues that need to be addressed by further investigation. Here, ICAM1 is linked to myocardial ischemia.