CXCL8 and myocardial ischemia: On one hand, interleukin-8 (IL-8) secreted after myocardial ischemia recruits bone marrow-derived mesenchymal stromal cells (MSCs) to the sites of degenerated tissue of myocardium by interacting with CXCR1 overexpressed on MSCs, thereby reducing the ischemic area and improving cardiac function (61).