CXCR1 and myocardial infarction: In conclusion, the combination of transcriptome analysis and subsequent RT-PCR, WB and IHC verification revealed that GXNI has a significant therapeutic effect on acute myocardial infarction in mice mainly via inhibiting the CXCR1-NF-κB-COX-2/ICAM-1/VCAM-1 pathway.