CXCR1 and acute myocardial infarction: Since GXNI treatment of acute myocardial infarction is mainly related to the anti-inflammatory effects mediated by CXCR1-NF-κB-COX-2/ICAM-1/VCAM-1-mediated IL-8 signaling pathway (Figures 3E, H), the release of inflammatory factors and leukocyte infiltration were further examined.