The expression of exosomal miR-21 and miR-155 is upregulated in SLE patients (77), and exosomal miR-146a is associated with the active lupus phase, proteinuria, and histological features, possibly by inhibiting the negative regulation of inflammation by IRAK1 and TRAF6 (78). The gene discussed is IRAK1; the disease is systemic lupus erythematosus.