In clinical practice, anti-Ro/SSA antibodies can be associated with a wide range of SARDs, such as subacute cutaneous lupus, neonatal lupus, systemic lupus erythematous (SLE), SjS, SjS/SLE overlap syndrome, myositis, rheumatoid arthritis (RA) and primary biliary cirrhosis (24–28). The gene discussed is TRIM21; the disease is systemic lupus erythematosus.