While lower fibrinogen (2.09 g/L, range: 1.60–2.56 g/L, P = 0.038) and more common decreased C4 (3/3, 100%, P = 0.033) were detected in CD8-predominant AITL than in common AITL cases. This evidence concerns the gene C4A and angioimmunoblastic T-cell lymphoma.