CD4 and angioimmunoblastic T-cell lymphoma: Although CD8-predominant AITL has histological features similar to those of common AITL, it has a lower TIL-B proportion, an inverted CD4+/CD8+ TIL-Ts ratio, deterioration of TR and IGH repertoire metrics, and altered gene expression profiles, indicating the anti-tumor immunity impairment in TME.