CD8-predominant AITLs had a significantly higher proportion of total TIL-Ts (CD8-predominant AITL: median: 60.8%, range: 45.4–70.3%, vs. common AITL: median: 37.8%, range: 17.4–65.8%, P = 0.025), CD8+TIL-Ts (CD8-predominant AITL: median: 47.5%, range: 33.6–64.0%, vs. common AITL: median: 16.9%, range: 7.4–35.5%, p < 0.001), and lower CD4+TIL-Ts (CD8-predominant AITL: median: 10.7%, range: 5.7–17.3%, vs. common AITL: median: 19.9%, range: 9.9–35.5%, P = 0.013). This evidence concerns the gene CD8A and angioimmunoblastic T-cell lymphoma.