CD8A and neoplasm: CD8-predominant AITLs displayed narrowed TRB and IGH repertoires in TME, showing a significant drop in productive clones and increased clonality score in the TRB repertoire, a decrease in entropy, and an increase in the proportion of the top 10 clones in the IGH repertoire, which also indicated the immunosuppressive TME and anti-tumor immunity impairment.