CD8-predominant AITLs had a higher proportion of the top 10 clones [CD8-predominant AITLs top 10 clones, 18.5% (range 12.7–56.5%) vs. common AITL top 10 clones, 11.1% (range 1.9–17.9%), P = 0.002], lower entropy [CD8-predominant AITLs median entropy 4.415 (range 4.229–4.526) vs. common AITL median entropy 4.589 (range 4.341–4.684), P = 0.027]. This evidence concerns the gene CD8A and angioimmunoblastic T-cell lymphoma.