AKT1 and neoplasm: Cur has been shown to regulate several cell signaling pathways, including cell survival (c-IAP1, cFLIP, Bcl-xL, Bcl-2, XIAP), cell multiplication (cyclin D1, c-myc), caspase stimulation (caspase-3, 8, 9), protein kinase (JNK, Akt, and AMPK), mitochondrial, death receptor (DR4, DR5), and tumor inhibitor (Yen et al., 2019).