Although current speculation is limited by the lack of experiments demonstrating the straightforward suppressive effects of caffeine on the NLRP3 inflammasome in cancer cells derived from oral cavity and oropharynx SCC and the subsequent inhibition of oral cancer growth, it is still confident that the cancer prevention effect of coffee on the oral cavity and oropharynx SCC stems from the inhibition of NLRP3 inflammasome activation by caffeine. The gene discussed is NLRP3; the disease is cancer.