MAPT and Alzheimer disease: The main pathological features of AD include brain atrophy, neuronal loss, intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein, and accumulation of amyloid-beta (Aβ) in cerebral vessels and brain parenchyma (DeTure and Dickson, 2019; Tiwari et al., 2019; Ma et al., 2021).