The presence of two or more WHO screening symptoms (1.83 (1.04–3.22)), one or more PoCUS individual features (2.89 (1.87-4.47)), one or more PoCUS independent features (2.89 (1.92-4.35)), urinary LF-LAM (6.70 (3.99-11.25)), current antiretroviral therapy use (0.46 (0.31-0.68)), CD4 cell count less than 100 cells/mm3 (1.98 (1.32-2.95)), and chest x-ray reported as ‘likely tuberculosis’ (4.81 (3.13-7.40)) were significantly associated with confirmed tuberculosis. The gene discussed is CD4; the disease is tuberculosis.