Of these, CA-199 (HR 1.002, 95% CI 1.001–1.003, P = 0.001), CEA (HR 1.009, 95% CI 1.003–1.016, P = 0.006), tumor diameter (HR 1.284 95% CI 1.045–1.576, P = 0.017), and T stage (HR 5.105, 95% CI 1.126–23.149, P = 0.035) were independent risk factors for OS, but HGB (HR 0.962, 95% CI 0.938–0.986, P = 0.002) was an independent protective factor. Here, CYGB is linked to neoplasm.