Several mutations previously reported to be significantly associated with an increased risk of severe liver disease progression to HCC and/or LC progression were also detected in other genes namely (rtD134E/rtF221Y/rtM204V/rtM309k) in the RT region; (sF22L) in the preS2 region; (sL49R, sL213I and sL216*) in the S region; (C1766T/T1768A double mutant, C1773T, C1799G, and C1766G) in the BCP region; and (cT12S/cE64D/cT67N/cA80T/cP130Q) in the core region of the C gene. The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.