The EVs have been identified as a potential cell-to-cell carrier of misfolded proteins associated with neurodegenerative diseases in the central nervous system in most neurodegenerative diseases, and Aβ peptide, viral protein, alpha synuclein, tau, and superoxide dismutase (SOD) pathogenic aggregates are released from cells as exosomes (Saman et al., 2012; Schneider and Simons, 2013). Here, MAPT is linked to neurodegenerative disease.