Konermann and colleagues assembled an all-in-one AAV vector of the above CRISPR system to treat Frontotemporal Dementia with Parkinsonism linked to Chromosome 17 (FTDP-17)—an autosomal dominant major neurodegenerative disease caused by diverse point mutations in MAPT, the gene encoding for the tau protein. The gene discussed is MAPT; the disease is neurodegenerative disease.