Stimulator of interferon genes (STING) is an important activator of immune response by promoting the production of Type 1 interferon and antigen presentation by myeloid cells, which is necessary for T cell activation and effective tumor cell killing.27–32 Recent studies have revealed that the cGAS-STING pathway activity is suppressed in GBM cells33 Its activation is known to contribute to anti-tumoral immune response,30,31 and cGAS-STING pathway activation is therefore an intriguing objective for IOs. Here, CGAS is linked to glioblastoma.