The effects of radiation therapy include activation of the innate and adaptive immune systems following radiation-associated DNA damage leading to robust STING-dependent and -independent type I IFN responses.101 Loss of STING has been associated with decreased reactive oxygen species and DNA double strands which suggest that STING agonists may increase tumor sensitivity to ionizing radiation.55 Certain preclinical study results support this possibility. This evidence concerns the gene STING1 and neoplasm.