Epigenetic modifications of the STING gene that influence STING expression have been shown in several cancer types as well as in STING-mediated chronic diseases.79–82 Analysis of CpG promotor sites using TCGA GBM Illumina methylation array data reveal that methylation of STING cg16983159 is inversely correlated with STING expression. This evidence concerns the gene STING1 and cancer.