A higher plasma PCSK9 was observed in subjects with hypertension (246.1 ± 53.8 vs. 207.6 ± 57.0, p = 0.03) and in non-smoking subjects (221.8 ± 58.6 vs. 185.8 ± 43.3, p = 0.043). The gene discussed is PCSK9; the disease is hypertensive disorder.