Since all three studies using LC-MS approaches found changes in the markers corresponding with non-classical RAAS activation (i.e., Ang-1–7/Ang-II ratio) to be more pronounced depending on COVID-19 disease severity, we advocate their potential, in contrast to Ang-II alone, as a prognostic biomarker which should be investigated in prospective studies. Here, ANGPT1 is linked to COVID-19.