These formulas, Yiguanjian decoction (Boriero et al., 2021), Sijunzi decoction (Xiong and Qian, 2013), Yupingfeng powder (Lai et al., 2020), Ganghuo Kanggan decoction (Lai et al., 2020), and Xin-Jia-Xiang-Ru-Yin (Li et al., 2018), were crucial for treating hepatic fibrosis, spleen deficiency, and influenza through inhibiting STAT1 signaling, whereas the other formula, Yu-Ping-Feng decoction, induces opposite effects on STAT1 activation to anti-cancer (Zhou et al., 2021). The gene discussed is STAT1; the disease is cancer.