As one member of the STAT family involved in transducing signals in response to IL-12, STAT4 plays an integral role in the generation of inflammation during immune responses and immune-mediated diseases, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and psoriasis (Yang et al., 2020b). The gene discussed is SOAT1; the disease is rheumatoid arthritis.