These extracts or active compounds belong to heat-clearing (Qingre) and dewetting (Zaoshi), heat-killed (Xiehuo), and detoxifying (Jiedu) traditional Chinese medicines and are used for treating inflammation and cancer in clinical formulas by regulating JAK/STAT alone, or its crosstalk with NF-κB, and Notch signaling. This evidence concerns the gene NFKB1 and cancer.