The extract of Sophorae Flos (SLE) (Liu et al., 2019), Rosae Multiflorae Fructus, and Lonicerae Japonicae Flos (RLE) decreased STAT3 signaling activation by antagonizing p-STAT3 and resulted in an inhibitory effect on inflammatory cytokines, which finally exerted their effects on RA and melanoma (Liu et al., 2019). Here, STAT3 is linked to rheumatoid arthritis.