STAT2 and ulcerative colitis: In particular, Mahuang tang and Yinqiao powder (Xue-mei, 2020) antagonized acute upper respiratory tract infection by activating STAT2, resulting in improving the immune barrier function of mouse nasal mucosa, whereas, Si-Ni-San inhibited STAT2 activation for alleviating ulcerative colitis (UC) (Cai et al., 2021).