Upregulation of cryptotanshinone on the expression of p-STAT5 supported protection against ischemic stroke (Zhu et al., 2021), whereas the inhibitory effect of cryptotanshinone effectively antagonized chronic myelocytic leukemia (CML) (Dong et al., 2018). Here, STAT5A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.