TS IIA and AS IV and TS IIA and Puerarin were presented here for their excellent performance in protecting against lumbar intervertebral disc degeneration (Du et al., 2021b) and idiopathic pulmonary fibrosis (IPF) (Xue et al., 2021) through restricting STAT1 cascade via combined utilization. Here, STAT1 is linked to idiopathic pulmonary fibrosis.