AKT1 and heart failure: It also improved left ventricular function in rats with heart failure induced by chronic myocardial infarction, reduced interstitial fibrosis by decreasing type I and type III collagen mRNA expression, and protected mitochondrial morphology, these changes may be related to reduced apoptosis and upregulation of VEGF expression, and in which AKT is involved (Liang et al., 2016).