AKT1 and obesity due to melanocortin 4 receptor deficiency: Phytochemicals like green tea component epigallocatechin-3 gallate and turmeric component curcumin have been shown to reduce obesity-associated polyp formation in animal models by inhibiting PI3K/Akt and MAPK signal pathways and have been suggested as a prevention strategy for obesity-associated colon cancer (92).